The US Army Air Corps eventually placed orders for over 1,300 C-45 aircraft and, of these, most (1,137) were delivered in the C-45F configuration (seven-seat passenger transport). Other variants included the original C-45, the C-45A, C-45B, C-45C, C-45D, C-45E, C-45G and C-45H models - differing mainly in internal configuration and expected role. The "Expeditor II" and "Expeditor III" names were given to British (Royal Navy) and Canadian (Air Force) examples, respectively, under Lend-Lease.
After World War 2 and into the volatile 1950s, the US military charged Beechcraft with refurbishing some 900 C-45 airframes and these were reconstituted into USAF service as the C-45G (autopilot, R-985-AN-3 radial engines) and C-45H (sans autopilot, R-985-AN-14B engines) of which many went on to serve into the 1960s (approx. 1963). Some were assigned to Strategic Air Command (SAC).
Every branch of American service eventually fielded some form of the Model 18, such was the reach of this fine little airplane.
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