Armament is a mix of projectile-based and missile-based weapons. There are 3 x 76mm OTO-Melara "Super Rapid " turreted main guns carried along with 2 x 25mm /80 caliber OTO-Melara (Oerlikon) autocannons. 2 x EuroTorp torpedo launchers handle a stock of MU90 lightweight torpedoes. The heart of this craft, however, is its DCNS "Sylver" A50, a 48-cell Vertical Launch System (VLS) housing either MBDA "Aster 15" or the longer-range MBDA "Aster 30" surface-to-air missiles (and additional sixteen cells are supported as needed). 8 x S/S Teseo Mk2/A missile launchers are also present. In 2017, a pair of SITEP LRAD MASS CS-424 acoustic guns were fitted to combat specialized threats to the ship.
The combination hangar/helo-deck set over the stern can launch and retrieve a medium-lift helicopter, typically the AgustaWestland AW101 or NHIndustries NH90 is seen. These helicopters can be utilized in the at-sea resupply role or modified to serve as Search and Rescue (SAR) or submarine/anti-ship platforms as needed, broadening the tactical value of the vessel.
Caio Duilio's profile exhibits many physical features consistent with modern ship design: an unbroken, full-length bow line, slab-sided panels, enclosed primary structures, etc... The smoke funnels are concentrated near midships and are fully-enclosed with a low-profile design approach used. The main mast, also wholly enclosed, sits atop the bridge superstructure while a secondary mast is set at midships with a third, shorter, mast set over the aft superstructure section. The flightdeck with its attached hangar facilities make up the stern section.
After acceptance into service in 2009, Caio Duilio joined her Horizon-class sisters (including the French twins) for joint exercises - the first time the quad were together in any one place. From there she participated in several celebratory actions and voyages during 2010 and into 2011. In the latter, she also partook in "Proud Manta 2011" which involved other NATO ocean-going elements. While managing a rather low-key, uneventful existence to date, the warship is wholly outfitted to undertake many roles for the Italian Navy including counter-piracy sorties, humanitarian/disaster relief, and convoy/battlegroup escort.
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